Pre-registered outcomes

Prediction / outcome matrix

For selected high-priority clinician questions, this matrix states in advance how a supportive, against, or inconclusive result would affect each listed hypothesis: strengthen, weaken, unchanged, or reframe. It does not predict a diagnosis, invent thresholds, or order tests.

Standing limits

Research instrument only. A licensed clinician decides whether any question is worth asking and how to interpret real results. Analysis version v0.4.1 · evidence current through 2026-08-10 · as of 2026-08-11.

All clinician questions · How this could be wrong

strengthenweakenunchangedreframe

CQ-001

Would paired bone formation markers (P1NP, bone-specific ALP ± osteocalcin), interpreted with preanalytical standards, help classify turnover before any long-term bone-agent class discussion?

Pre-registered qualitative outcomes for CQ-001. Not a diagnostic scorecard.
Hypothesis	If result supports the research question’s intended signal	If result argues against that signal	If inconclusive / unavailable
H3	strengthen	weaken	unchanged
H2	reframe	unchanged	unchanged
H-NULL	weaken	strengthen	unchanged

CQ-002

On the next same-scanner DXA, can age-appropriate Z-scores be reported and can hip BMD change be interpreted against a facility-derived LSC? If vertebral fracture assessment (VFA) is considered, does the patient meet formal indication criteria rather than low BMD alone? Trabecular bone score (TBS), if discussed, is per ISCD generally for ages ≥40 with male fracture-risk evidence primarily studied above age 50 — this patient is ~38, so is TBS applicable now, or better deferred?

Pre-registered qualitative outcomes for CQ-002. Not a diagnostic scorecard.
Hypothesis	If result supports the research question’s intended signal	If result argues against that signal	If inconclusive / unavailable
H2	strengthen	weaken	unchanged
H1	strengthen	unchanged	unchanged
H-NULL	weaken	strengthen	unchanged

CQ-003

Is controlled calcium-flux phenotyping (sodium-aware 24h urine with stone profile + fasting urine Ca/Cr + paired serum Ca/PTH/PO4) appropriate to classify hypercalciuria mechanism?

Pre-registered qualitative outcomes for CQ-003. Not a diagnostic scorecard.
Hypothesis	If result supports the research question’s intended signal	If result argues against that signal	If inconclusive / unavailable
H3	strengthen	weaken	unchanged

CQ-005

Can high-sensitivity peripheral-blood KIT D816V testing be performed with specimen, method, and limit of detection documented?

Pre-registered qualitative outcomes for CQ-005. Not a diagnostic scorecard.
Hypothesis	If result supports the research question’s intended signal	If result argues against that signal	If inconclusive / unavailable
H1	strengthen	weaken	unchanged
H-NULL	weaken	strengthen	unchanged

CQ-009

If infection is re-adjudicated, are reference Babesia thin smear + PCR during symptoms and Bartonella culture/PCR/IFA (or tissue only if a safe target exists) the appropriate instruments — rather than IgM churn or post-antibiotic FISH as primary adjudicators?

Pre-registered qualitative outcomes for CQ-009. Not a diagnostic scorecard.
Hypothesis	If result supports the research question’s intended signal	If result argues against that signal	If inconclusive / unavailable
H4	strengthen	weaken	unchanged
H-NULL	weaken	strengthen	unchanged

What this page does not do

It does not name a diagnosis or preferred treatment.
It does not turn research questions into test orders or consumer instructions.
It does not assign numeric probabilities or post-hoc re-rank scores after results arrive.