lit-0294
Primary Osteoporosis in Young Adults: Genetic Basis and Identification of Novel Variants in Causal Genes
Collet C, Ostertag A, Ricquebourg M, Delecourt M, Tueur G, Isidor B, Guillot P, Schaefer E, Javier RM, Funck-Brentano T, Orcel P, Laplanche JL, Cohen-Solal M (2018). JBMR Plus.
Study design and applicability are separate. A rigorous design in an unmatched population is not “strong evidence” for this record.
Status: Bibliographic identity verified (identifier match only). Identifier resolution proves bibliographic identity only; it does not prove that the card summary supports any medical claim, and it is not clinician review. Semantic verification count remains 0 for the catalog.
Cohort of 123 young/middle-aged adults with idiopathic OP (Z-score < −2.0, diagnosis before age 55, fracture optional). Secondary causes including hypogonadism were EXCLUSIONS. Yield figures must state numerator/denominator/variant class. Identifiers verified Crossref+NCBI 2026-08.
Record overlap notes (research). age-under-55 markedly low BMD (directional only); NOT a match on idiopathic-after-excluding-hypogonadism cohort definition; candidate genes LRP5 WNT1 PLS3 COL1 remain research-relevant, not yield-transferable
DOI: 10.1002/jbm4.10020 · PMID: 30283887 · PMCID: PMC6124172
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