lit-0205
Specific Antibody Deficiency: Controversies in Diagnosis and Management
Perez E, Bonilla FA, Orange JS, Ballow M (2017). Frontiers in Immunology.
Study design and applicability are separate. A rigorous design in an unmatched population is not “strong evidence” for this record.
Status: Bibliographic identity verified (identifier match only). Identifier resolution proves bibliographic identity only; it does not prove that the card summary supports any medical claim, and it is not clinician review. Semantic verification count remains 0 for the catalog.
Consensus-style expert review; defines SAD and diagnostic controversies. Essential for interpreting pneumo/Hib titers. Published corrigendum: Front Immunol 2018 (doi 10.3389/fimmu.2018.00450, PMID 29576764) — check publisher record.
Record overlap notes (research). non-protective Hib IgG (0.33; protective ≥1.00); many pneumococcal serotypes low (<0.3); normal total IgG with Ig subclass skew (IgG4↑/IgG1↓); recurrent infection history (childhood respiratory/ear)
DOI: 10.3389/fimmu.2017.00586 · PMID: 28588580 · PMCID: PMC5439175
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