lit-0021
Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs
Whitfield KC, Bourassa MW, Adamolekun B, Bergeron G, Bettendorff L, Brown KH, Cox L, Fattal-Valevski A, Fischer PR, Frank EL, Hiffler L, Hlaing LM, Jefferds ME, Kapner H, Kounnavong S, Mousavi MPS, Roth DE, Tsaloglou MN, Wieringa F, Combs GF Jr (2018). Annals of the New York Academy of Sciences.
Study design and applicability are separate. A rigorous design in an unmatched population is not “strong evidence” for this record.
Status: Bibliographic identity verified (identifier match only). Identifier resolution proves bibliographic identity only; it does not prove that the card summary supports any medical claim, and it is not clinician review. Semantic verification count remains 0 for the catalog.
Landmark biomarker/diagnosis roadmap; ~80% of whole-blood thiamine is erythrocyte ThDP. ETK more informative functionally; ETKAC best biochemical evidence of deficiency but limited by availability. Plasma/serum thiamine is a bidirectional-weak status indicator.
Record overlap notes (research). serum B1 7 nmol/L lab interpretation context; biomarker uncertainty
DOI: 10.1111/nyas.13919 · PMID: 30151974 · PMCID: PMC6392124
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- Hypothesis H1 (supporting)